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The brain derived neurotrophic factor mRNA level changes following trainsient focal brain ischemia and reperfusion in brain

MI Runfa

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Abstract

Objective: To study the change of brain derived neurotrophic factor mRNA (BDNFmRNA)in hippocampus and the effect of BDNF on the hippocampus neurons after focal cerebral ischemia and reperfusion in rats.Methods:The level of BDNFmRNA was measured in the rat hippocampus using in situ hybridization.Results :(1)The level of BDNFmRNA in the bilateral hippocampus was increased after cerebral ischemia and reperfusion.(2)The lower level of BDNFmRNA in the hippocampus with serious ischemia was found than that with slight ischemia.(3)The level of BDNFmRNA following the reperfusion was increased continuously.It was the highest at 12 hours and recovered basal level at 72 hours after the reperfusion.Conclusion: The regional basal BDNFmRNA level showed here positively correlated with cellular resistance to ischemic damage,and it was consistent with the hypothesis of a neuroprotective role of BDNF.

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Objective: To study the change of brain derived neurotrophic factor mRNA (BDNFmRNA)in hippocampus and the effect of BDNF on the hippocampus neurons after focal cerebral ischemia and reperfusion in rats.Methods:The level of BDNFmRNA was measured in the rat hippocampus using in situ hybridization.Results :(1)The level of BDNFmRNA in the bilateral hippocampus was increased after cerebral ischemia and reperfusion.(2)The lower level of BDNFmRNA in the hippocampus with serious ischemia was found than that with slight ischemia.(3)The level of BDNFmRNA following the reperfusion was increased continuously.It was the highest at 12 hours and recovered basal level at 72 hours after the reperfusion.Conclusion: The regional basal BDNFmRNA level showed here positively correlated with cellular resistance to ischemic damage,and it was consistent with the hypothesis of a neuroprotective role of BDNF.

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Available abstract

Objective: To study the change of brain derived neurotrophic factor mRNA (BDNFmRNA)in hippocampus and the effect of BDNF on the hippocampus neurons after focal cerebral ischemia and reperfusion in rats.Methods:The level of BDNFmRNA was measured in the rat hippocampus using in situ hybridization.Results :(1)The level of BDNFmRNA in the bilateral hippocampus was increased after cerebral ischemia and reperfusion.(2)The lower level of BDNFmRNA in the hippocampus with serious ischemia was found than that with slight ischemia.(3)The level of BDNFmRNA following the reperfusion was increased continuously.It was the highest at 12 hours and recovered basal level at 72 hours after the reperfusion.Conclusion: The regional basal BDNFmRNA level showed here positively correlated with cellular resistance to ischemic damage,and it was consistent with the hypothesis of a neuroprotective role of BDNF.

Key concepts: Hippocampus, Ischemia, Neuroprotection, Neurotrophic factors, Basal (medicine), Brain-derived neurotrophic factor, Internal medicine, Endocrinology

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The brain derived neurotrophic factor mRNA level changes following trainsient focal brain ischemia and reperfusion in brain — Research Paper | ScholarLens