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2004•Unpublished venueRequires access

The experimental study and clinical application progress of ~(18)F,fluorothymidine

Sun Xiao

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Abstract

deoxy,3′,18F,fluorothymidine(18F,FLT) is a promising tracer derived from thymidine. Accumulation of 18F,FLT is dependent on cellular thymidine kinase,1(TK,1) activity. This enzyme is functional only in cells undergoing DNA replication during the S phase of the cell cycle.18F,fluo,rothymidine PET thus be able to image of cell proliferation in vivo for diagnosis, staging and moni,toring of treatment re,sponse. Its advancements in basic and clinical studies will be reviewed in this article.

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What this paper is about

deoxy,3′,18F,fluorothymidine(18F,FLT) is a promising tracer derived from thymidine. Accumulation of 18F,FLT is dependent on cellular thymidine kinase,1(TK,1) activity. This enzyme is functional only in cells undergoing DNA replication during the S phase of the cell cycle.18F,fluo,rothymidine PET thus be able to image of cell proliferation in vivo for diagnosis, staging and moni,toring of treatment re,sponse. Its advancements in basic and clinical studies will be reviewed in this article.

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Available abstract

deoxy,3′,18F,fluorothymidine(18F,FLT) is a promising tracer derived from thymidine. Accumulation of 18F,FLT is dependent on cellular thymidine kinase,1(TK,1) activity. This enzyme is functional only in cells undergoing DNA replication during the S phase of the cell cycle.18F,fluo,rothymidine PET thus be able to image of cell proliferation in vivo for diagnosis, staging and moni,toring of treatment re,sponse. Its advancements in basic and clinical studies will be reviewed in this article.

Key concepts: Thymidine kinase, Thymidine, In vivo, Cell cycle, DNA replication, Cell growth, Cell biology, Cell

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