Effect of propofol on renal histopathological changes during acute renal ischemia/reperfusion injury in rats

Objective:To investigate the effects of propofol on renal histopathological changes during acute renal ischemia/reperfusion injury in rats.Methods:A total of 50 SD rats were randomly and equally divided into sham operation group(group C),renal ischemia/reperfusion group(group I),propofol pretreatment group(group P1),propofol simultaneous treatment group(group P2),and propofol post-treatment group(group P3).The rats in groups P1,P2,and P3 were infused with 30 mg·kg-1·h-1 of propofol 1 hour before the occlusion of renal artery for 3 hours,simultaneously with the occlusion of renal artery for 4 hours,simultaneously with the reperfusion for 4.75 hours,respectively.The rats were killed 24 hours later.The renal tissues were observed after HE staining,and the changes in the levels of malondialdehyde(MDA),superoxide dismutase(SOD),and Ca2+ were measured.Results:Compared with group I,in groups P1 and P2,the renal histopathological changes were less severe,the levels of MDA and Ca2+ significantly decreased,and the activity of SOD significantly increased(P0.01 or P0.05).No such effects were found in group P3.Conclusion:The pretreatment or simultaneous treatment with propofol can ameliorate renal injuries after ischemia/reperfusion,but post-treatment has not such protective effect.