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2011•Shiyong yixue zazhiRequires access

Chronic infection of duck hepatitis B virus resistant to lamivudine

Hou Jin-li

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Abstract

Objective To build and investigate the chronic infections of duck hepatitis B virus resistant to lamivudine.Methods Ducklings were infected with DHBV wild and its lamivudine-resistant strain.Serial serum viral loads were quantified during 70 days observation;Intrahepatic DHBV DNA and cccDNA were detected by Southern blot and histological changes were evaluated.Results The viral loads and persistent infection rate of wild-type group was greater than resistant.Expected DHBV replicative intermediates including cccDNA and mild inflammation existed.Conclusion The lamivudine-resisted DHBV could develope de novo chronic infection.

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What this paper is about

Objective To build and investigate the chronic infections of duck hepatitis B virus resistant to lamivudine.Methods Ducklings were infected with DHBV wild and its lamivudine-resistant strain.Serial serum viral loads were quantified during 70 days observation;Intrahepatic DHBV DNA and cccDNA were detected by Southern blot and histological changes were evaluated.Results The viral loads and persistent infection rate of wild-type group was greater than resistant.Expected DHBV replicative intermediates including cccDNA and mild inflammation existed.Conclusion The lamivudine-resisted DHBV could develope de novo chronic infection.

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Available abstract

Objective To build and investigate the chronic infections of duck hepatitis B virus resistant to lamivudine.Methods Ducklings were infected with DHBV wild and its lamivudine-resistant strain.Serial serum viral loads were quantified during 70 days observation;Intrahepatic DHBV DNA and cccDNA were detected by Southern blot and histological changes were evaluated.Results The viral loads and persistent infection rate of wild-type group was greater than resistant.Expected DHBV replicative intermediates including cccDNA and mild inflammation existed.Conclusion The lamivudine-resisted DHBV could develope de novo chronic infection.

Key concepts: Lamivudine, Duck hepatitis B virus, cccDNA, Virology, Biology, Virus, Hepatitis B virus, Chronic hepatitis

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