Treatment effect of cyproterone acetatea combined with insulin sensitizer on nonobese patients with polycystic ovary syndrome and insulin resistance

Objective:To observe the treatment effect of insulin sensitizing agents-metformin and rosiglitazone combined with cyproterone acetatea(CPA) on nonobese women with polycystic ovary syndrome(PCOS) and insulin resistance(IR).Methods:68 patients with PCOS and IR were randomly divided into group A,B and C.26 patients in group A were given cyproterone acetatea(CPA) for 3 months,23 patients in group B were given metformin and CPA for 3 months.19 patients in group C were given CPA and Rosiglitazone for 3 months.The clinical feature,reproductive hormone,OGTT,IRT,Homa IR,Homaβ and AUCINS were observed and calculated before and after CPA or insulin sensitizing agents treatment.Results:After 3 months treatment with CPA or insulin sensitizers,the serum T level and LH/FSH decreased in both A,B and C groups.The index of glucose metabolism and insulin resistance were significantly improved as compared with those of pretreatment in B and C group also.But there were no significant difference between group B and C.Conclusion:Insulin sensitizing agents-rosiglitazone and metformin used to treat PCOS women with insulin resistance and hyperinsulinemia is a quite effective method,there is no significant difference between metformin and rosiglitazone about their treatment effect,metformin would be commended according to safety and payment.