Multilateral analysis of prognostic factors on HBV intrauterine infection

Objective To investigate the HBV infectious rate of HBV carrier mothers and later of their infants.Methods HBV carrier mothers and later their infants.57 mothers and their 57 infants were followed for 9-18 months.Their serum was investigated.HBVM was measured by ECL methods.HBV-DNA was detected by Q-PCR.Results Seven cases of 57 newborn infants were observed infected.The rate of infection was 12.28%.Comparing with peripheral venous blood sample,the sensitivity and positive predictive value of HBV detected in cords was 100.00%,80.00%respectively.9-18 months later,12 cases of the infants became HBV chronic carriers.The fetal infectious rate in mothers with HBeAg or HBV-DNA positive was 86.67%,100%,respectively,which was significantly higher than that in mothers with HBeAg or HBV-DNA negative(P0.01).Conclusion HBeAg or HBV-DNA positive in mothers is one of the risk factors of intrauterine infection.Detection of HBV-DNA in cord blood is a sensitive index for diagnosing fetal infection,however,detection of peripheral venous blood is with the significance of making correct diagnosis.