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Preparation of 5-Fluorouracil-loaded Nanocapsules

Wei Li

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Abstract

Nanocapsules loaded with 5-fluorouracil(5-Fu) were prepared by interfacial polymerization, with _α_-butylcyanoacrylate being chosen as carrier. The nanocapsules were uniformly spherical and the average diameter was 232 nm(_n_=300) as seen by scanning electron microscopy(SEM). The drug loading of the 5-Fu nanocapsules was 30% as tested by ultraviolet spectroscopy(UV). The behavior of drug release in vitro indicate that nanocapsules bake on sustained-release character.

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What this paper is about

Nanocapsules loaded with 5-fluorouracil(5-Fu) were prepared by interfacial polymerization, with _α_-butylcyanoacrylate being chosen as carrier. The nanocapsules were uniformly spherical and the average diameter was 232 nm(_n_=300) as seen by scanning electron microscopy(SEM). The drug loading of the 5-Fu nanocapsules was 30% as tested by ultraviolet spectroscopy(UV). The behavior of drug release in vitro indicate that nanocapsules bake on sustained-release character.

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Available abstract

Nanocapsules loaded with 5-fluorouracil(5-Fu) were prepared by interfacial polymerization, with _α_-butylcyanoacrylate being chosen as carrier. The nanocapsules were uniformly spherical and the average diameter was 232 nm(_n_=300) as seen by scanning electron microscopy(SEM). The drug loading of the 5-Fu nanocapsules was 30% as tested by ultraviolet spectroscopy(UV). The behavior of drug release in vitro indicate that nanocapsules bake on sustained-release character.

Key concepts: Nanocapsules, Scanning electron microscope, Polymerization, Materials science, Fluorouracil, Chemical engineering, Chemistry, Nanotechnology

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