A Comparative Study of Preventive Results of Granisetron,Tropisetron,and Ondansetron to Nausea and Emesis Induced by Cisplatin in Patients with Head and Neck Cancers

Objective: To evaluate the clinical efficacy and adverse effects of three 5-HT3 antagonists(granisetron,tropisetron,and ondansetron that produced in china) for the prevention of cisplatin-induced nausea and emesis in patients with head and neck cancers.Methods: Sixty-three patients that treated with high dose(80-100 mg/m2) of cisplatin for 90 cycles following chemotherapeutic regimens were ramdomly divided into three groups to receive antiemetic drugs including granisetron,tropisetron,and ondansetron.Results: The efficacy rates of granisetron,tropisetron,and ondansetron were 93.3%,86.7%,and 83.3% respectively(P0.05).Their side-effects were similar which were frequent constipation,fatigue and headache,but were mild and bearable.Conclusions: granisetron,tropisetron,and ondansetron are effective drugs in prevention of cisplatin-induced emesis in patients with head and neck cancers.