SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF SOME NOVEL CEPHEM ANTIBIOTICS Research Article

In the present communication a number of semisynthetic cephalosporins (1 - 9) have been synthesized and characterized by UV, 1H NMR, 13C NMR spectra and also, evaluated for their antibacterial activities in vitro against a number of pathogenic bacterial strains. The compounds 7, 8 and 9 have shown highly encouraging results as antibacterials with MIC in the range 0.391 to 0.097 µg/mL and molecules 1 – 6 have shown substantial degree of inhibitory action towards most of the bacteria screened in the present study. Thus, all the newly synthesized cephem antibiotics are acting as broad-spectrum antibacterial agents. The enhanced activity of these drugs may be due to increased concentration of drugs at the target site because all the molecules are having biodegradable ester bonds. Moreover, these newly synthesized cephem antibiotics are using enzymatically produced 7ACA as an intermediate thus leading to more economical and environmental friendly synthesis.