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2013•Zhongguo bingli shengli zazhiRequires access

STIM1 and Orai1 as novel targets for treating vascular diseases

Fang He

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Abstract

Endoplasmic reticulum calcium(Ca2+) sensor stromal interaction molecule 1(STIM1) and plasma membrane Ca2+ channel Orai1 are the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+ current(ICRAC).We have uncovered the protein expression of STIM1 and Orai1 in various tissues and described many kinds of roles for these proteins under physiological and pathophysiological conditions.Here,we summarize the novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the treatment of vascular diseases.

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What this paper is about

Endoplasmic reticulum calcium(Ca2+) sensor stromal interaction molecule 1(STIM1) and plasma membrane Ca2+ channel Orai1 are the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+ current(ICRAC).We have uncovered the protein expression of STIM1 and Orai1 in various tissues and described many kinds of roles for these proteins under physiological and pathophysiological conditions.Here,we summarize the novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the treatment of vascular diseases.

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Available abstract

Endoplasmic reticulum calcium(Ca2+) sensor stromal interaction molecule 1(STIM1) and plasma membrane Ca2+ channel Orai1 are the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+ current(ICRAC).We have uncovered the protein expression of STIM1 and Orai1 in various tissues and described many kinds of roles for these proteins under physiological and pathophysiological conditions.Here,we summarize the novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the treatment of vascular diseases.

Key concepts: STIM1, ORAI1, Endoplasmic reticulum, Cell biology, Pathophysiology, Calcium signaling, Chemistry, Biology

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