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The Research Progress of Zona Pellucida Glycoprotein in Mammalian Species

Tian Li

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Abstract

The sperm recognizing to eggs is completed in mammalian species by sperm head glycoproteins specific binding to a complementary glycoproteins located on the egg ZP.The egg ZP is constructed of three glycoproteins,termed ZP1,ZP2,ZP3.One of the ZP glycoproteins,ZP3,serves as the first receptor for spermatozoa,binds free swimming acrosome intact spermatozoa,and induce the acrosome reaction(AR).After ZP3 mediated acrosomal execytosis,the spermatozoa is postulated to bind to the secondary receptor,ZP2,ZP1,is the homodimeric filament crosslinker between ZP2 and ZP3.The ZP antigen immunization results in premature ovarian failure(POF).The antibody induced by ZP α、β serving as heterogeneous carrier proteins inhibits sperm binding to eggs.

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What this paper is about

The sperm recognizing to eggs is completed in mammalian species by sperm head glycoproteins specific binding to a complementary glycoproteins located on the egg ZP.The egg ZP is constructed of three glycoproteins,termed ZP1,ZP2,ZP3.One of the ZP glycoproteins,ZP3,serves as the first receptor for spermatozoa,binds free swimming acrosome intact spermatozoa,and induce the acrosome reaction(AR).After ZP3 mediated acrosomal execytosis,the spermatozoa is postulated to bind to the secondary receptor,ZP2,ZP1,is the homodimeric filament crosslinker between ZP2 and ZP3.The ZP antigen immunization results in premature ovarian failure(POF).The antibody induced by ZP α、β serving as heterogeneous carrier proteins inhibits sperm binding to eggs.

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Available abstract

The sperm recognizing to eggs is completed in mammalian species by sperm head glycoproteins specific binding to a complementary glycoproteins located on the egg ZP.The egg ZP is constructed of three glycoproteins,termed ZP1,ZP2,ZP3.One of the ZP glycoproteins,ZP3,serves as the first receptor for spermatozoa,binds free swimming acrosome intact spermatozoa,and induce the acrosome reaction(AR).After ZP3 mediated acrosomal execytosis,the spermatozoa is postulated to bind to the secondary receptor,ZP2,ZP1,is the homodimeric filament crosslinker between ZP2 and ZP3.The ZP antigen immunization results in premature ovarian failure(POF).The antibody induced by ZP α、β serving as heterogeneous carrier proteins inhibits sperm binding to eggs.

Key concepts: Zona pellucida, Glycoprotein, Zona pellucida glycoprotein, Acrosome reaction, Acrosome, Sperm, Cell biology, Receptor

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