Analysis of relative factors of heart valve calcification in patients with refractory secondary hyperparathyroidism

Objective To analyze the incidence of heart valve calcification( VC) and the possible factors of heart valve calcification among patients with refractory secondary hyperparathyroidism. Methods A total of 83 cases with refractory SHPT treated with parathyroidectomy( PTX) were retrospectively studied. The levels of hemoglobin( Hb),albumin( Alb),calcium( Ca2 +),phosphorus( P),alkaline phosphatase( ALP),CRP and intact parathyroid hormone( iPTH) were detected before hemodialysis. Heart valve calcification and parameters relating to cardiac structure and function were assayed,the patients were then assigned into the VC group and the no VC group. Laboratory and clinical data were compared between the two groups,then analyzed the possible factors contribute to VC. Results The incidence of VC were 47%( 39/83) in SHPT patients. Mitral valve calcification were found in 18 patients( 46.15%),mitral and aortic valve calcification in 17 patients( 43. 59%),aortic valve calcification in 4 patients( 10. 26%),43. 37%( 36 /83) of patients had a heart valve regurgitation( mitral valve and aortic valve). The level of SBP,DBP,iPTH,ALP,LA,LVDd in VC group were significantly higher than those in no VC group( all P 0. 05). Logistic regression found that PTH and LA were the independent factors for VC. Conclusions The incidence of VC in refractory SHPT are high,The level of iPHT is the independent impact factors for VC in refractory SHPT. Such patients should be considered for PTX as early as possible in order to slow the progress of VC and improve prognosis.