Association between genetic polymorphism of CYP1A1,XRCC1 and susceptibility to lung cancer

Aim:To study the association between genetic ploymorphism of cytochromp(CYP)1A1,X-ray repair cross complementing group 1(XRCC1)and lung cancer.Methods:Using PCR-RFLP to detect genetic ploymorphism of CYP1A1 and XRCC1 in 100 cases of lung cancer and 100 normal controls.Results:The frequencies of CYP1A1 mutational genotype in lung cancer group and control group were 11.0% and 17.0%,respectively,and there was no significant difference(χ2=3.163,P0.05).The frequencies of XRCC1 mutational genotype were 44.0% and 22.0% in lung cancer group and control group,respectively,and there was significant difference(χ2=13.472,P0.001).There was increased risk of lung cancer for individuals carrying mutational genotype of XRCC1 [OR=3.316(95%CI 1.729～6.359)]compared with subjects carrying wild genotype.Joint analysis of the two genes suggested that there was increased risk of lung cancer for individuals carrying both mutational genotype of XRCC1 and mutational genotype of CYP1A1 compared with subjects carrying single mutational genotype of CYP1A1 or XRCC1[OR=6.243(95%CI 2.286～17.046)].Conclusion:The mutational genotype of CYP1A1 and XRCC1 may contribute to the risk of developing lung cancer.