Effects of Xuefurong Capsule on the Sports Ability and c-fos Expression within Nac in Overload Training Rats

Objective:To explore the effects of Xuefurong capsule on the time of exhausted treadmill,the level of serum testosterone,lactic acid(LA),the PH of blood plasma,and expression of c-fos within nucleus accumbens(Nac) of brain in the male rats.Method: 30 SD rats were randomly divided into 3 groups: the sedentary control group,the training group,and the Chinese-medicine and training group.The Chinese-medicine and training group were forced to take Xuefurong capsule every day(5mg/kg) and lasted 8 weeks.Then the time of exhausted treadmill of rats was tested,the level of serum testosterone,the LA and the PH of blood plasma were examined,c-fos expression within Nac was detected and analysised by using ABC immunohistochemical technique and semi quantitative.Result: Compared with the training group,the time of exhausted treadmill was prolonged(P0.01),the level of testosterone and PH of blood plasma increased(P0.05,P0.05),the level of LA decreased(P0.05);The amount and area of c-fos within Nac obviously decreased(P0.05),the gray degree was not significant different(P0.05) in the Chinese medicine and training group.Conclusion: Taking Xuefurong capsules may enhance the sports ability,its mechanism might be that Xuefurong capsule increase the level of serum testosterone and PH blood of plasma,decrease the level of serum LA and excessive expression of c-fos within Nac at the same time.