2002•Northwest Pharmaceutical JournalRequires access
Study on the main pharmacokinetics of Sanling Jiangtang capsules
Song Jie
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Abstract
Objective To observe the effect of Sanling Jiangtang capsules on the experimental diabetes rats that caused by streptozotocin(STZ) and by alloxan, and on blood sugar and sugar tolerance in normal rats. Method STZ-induced rats and alloxan-induced rats were administrated of Sanling Jiangtang capsules(three concentrations) for 5 days and 10 days, respectively. Then the values of blood sugar and of sugar tolerance were observed. Results Sanling Jiangtang capsules can significently reduce the values of blood sugar in alloxan-induced diabetes rats(P0.01); and high-concentration and middle-concentration can clearly deminish the blood sugar level in STZ-induced diabetes rats(P0.05); as far as normal rats, the high-concentration and middle-concentration also have the falling effect(P0.01, P0.05). The middle-concentration can decrease the value of sugar tolerance in normal rats. Conclusion The above results suggest that Sanling Jiangtang capsules have preventive effect on normal rats, alloxan-induced diabetes rats, and STZ-induced diabetes rats.