2012•Journal of Logistics University of CAPFRequires access

Tumour cells apotosis mediated by TGF-β/Smad and TGF-β/MAPK pathway

Wencheng Zhang

Abstract

The transforming growth factor beta,TGF-β,is a kind of versatile cytokines.It is which participate in regulating cell proliferation,differentiation,apoptosis and other life activities.TGF-β in the regulation of tumor cell apoptosis is complex.TGF-β/Smad and TGF-β/MAPK pathway is the TGF-β mediated apoptosis of two important downstream signal transduction pathways.This article focuses on the TGF-β activation of Smad pathways and(or) MAPK pathway mediated tumor cell apoptosis and the role started to explore.

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Key concepts: SMAD, Transforming growth factor, MAPK/ERK pathway, Apoptosis, Signal transduction, Cell biology, Cancer research, Transforming growth factor beta