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The real-time optic fiber chemical sensor dissolution test detection method and conditions for compound amiloride hydrochloride tablets

Wu Jun

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Abstract

Objective:To study a method which can monitor the dissolution rate of drug on-line-fiber optic chemical sensor dissolution test(FOCSDT).And compare the difference of this method with CHP(2000).Method: By mean of FOCSDT,bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel.The dissolution procession could be monitored through computer.Result:This pro- cession analysis could test the whole process of drug and get dissolution graph.The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000(P0.05).Conclution:This procession anal- ysis can reflect the real dissolution of drug and obtain the total information.

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What this paper is about

Objective:To study a method which can monitor the dissolution rate of drug on-line-fiber optic chemical sensor dissolution test(FOCSDT).And compare the difference of this method with CHP(2000).Method: By mean of FOCSDT,bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel.The dissolution procession could be monitored through computer.Result:This pro- cession analysis could test the whole process of drug and get dissolution graph.The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000(P0.05).Conclution:This procession anal- ysis can reflect the real dissolution of drug and obtain the total information.

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Available abstract

Objective:To study a method which can monitor the dissolution rate of drug on-line-fiber optic chemical sensor dissolution test(FOCSDT).And compare the difference of this method with CHP(2000).Method: By mean of FOCSDT,bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel.The dissolution procession could be monitored through computer.Result:This pro- cession analysis could test the whole process of drug and get dissolution graph.The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000(P0.05).Conclution:This procession anal- ysis can reflect the real dissolution of drug and obtain the total information.

Key concepts: Dissolution, Chemical sensor, Dissolution testing, Chemistry, Chromatography, Analytical Chemistry (journal), Organic chemistry, Electrode

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The real-time optic fiber chemical sensor dissolution test detection method and conditions for compound amiloride hydrochloride tablets — Research Paper | ScholarLens