The collateral circulation and the influential factors in patients with severe stenosis or occlusion of middle cerebral artery

Objective To explore the relationship between the degree of middle cerebral artery stenosis and the frequency and type of collateral circulation compensatory;then to analyse the factors that influenced the set up of collateral circulation of middle cerebral artery. Methods The clinical data of 78 cases of patients with MCA stenosis were retrospective analyzed. Results There was significant difference between the different degree of MCA stenosis and availability of collateral circulation(P=0.002). There also was a significant difference between the different degree of stenosis and its collateral circulation type(P=0.024). Comparing the difference of stroke risk factors(hypertension,hyperlipidemia,diabetes)between the groups with and without collateral circulation,we found that only the difference of collateral circulation between patients with diabetes and patients without diabetes showed significance(P=0.009). The independent variables impacting the establishment of collateral circulation were degree of stenosis(OR=4.147,P=0.003)and lipids(OR=7.526,P=0.015). Conclusion The higher degree of middle cerebral artery stenosis,the higher the frequency of collateral circulation compensatory and the higher level of the collateral circulation opening up. Diabetes is not conducive to the seting up of the secondary collateral circulation after middle cerebral artery stenosis. Hyperlipidemia and the degree of MCA stenosis play a promotive role for the establishment of the secondary collateral circulation. There is no significant relationship between hypertention and the seting up of collateral circulation.