Study on Immunity Function in Children Infected by Epstein-Barr Virus

Objective To study immunity variation in children infected by Epstein-Barr virus(EBV) and its relation with clinical features.Methods Expression of CD3~+,CD4~+,CD8~+,CD_(19)~+,CD_(23)~+ on lymphocytes in peripheral blood were measured by flow cyto-(metry)(FCM) in 30 infectious monocleosis(IM)cases,who was in acute and convalescent phase,and in 20 healthy controls.Results The levels of CD4~+,CD8~+,CD_(19)~+,CD_(23)~+ on lymphocytes in peripheral blood were(14.88±3.14)%,(65.49±5.33)%,(5.70±(2.89)%,)((2.41±)1.83)% in 30 IM during acute phase and(36.75±3.88)%,(41.64±5.11)%,(15.98±2.80)%,(5.02±(2.76))% in 20 IM duing convalescent stage.The level of CD8~+ increased significantly,while the others decreased significantly in all IM in acute phase,compared with those of 20 IM in convalescent stage and those of healthy controls subjects.There were 3 cases whose levels of CD_(23)~+ were much higher in convalescent stage.Conclusions The abnormality of subset of lymphocytes in peripheral blood in children(affected) with EBV is obviously and persisted till convalescent stage.It is possible for persistent heightening CD_(23)~+ to become indication which can estimate progress for IM,but it needs more similar cases to follow and vadidate in long period.