Long-term effects of Helicobacter pylori infection on gatric mucosa and the influencing facter of outcome

Objective To study long-term effects of Helicobacter pylori (H. pylori) infection on gastric mucosa and nfluencing factors of outcomes of Long-term H.pylori infection.Methods The 114 patients who was H. pylori positive before decade were examined by endoscopy and pathology and the contents of serum Anti-Hp CagA-IgG and anti-Hp IgE of 80 patients who was persistent H. pylori infection for 10 years was examined.Results 34/114(29.8%) patients were H. pylori negative and 80/114(70.2%) patients persistent H. pylori positive. In H.pylori persistent positive patients, After decade the incidence of peptic ulcer was increased significantly, the incidence of intestinal metaplasia and erosion of gastric mucosa was increased significantly, the degree of gastritis and intestinal metaplasia was aggravated significantly. But in H. pylori negative patients, the incidence of peptic ulcer and the degree of gastritis were lower significantly in after decade than before decade and that of H. pylori persistent positive patients. In H.pylori negative patients, The erosion of gastric mucosa dissolved after decade, but the incidence and degree of intestinal metaplasia did not changed. After H. pylori persistent infection for 10 years , The positive rate of serum anti-Hp CagA-IgG and anti-Hp IgE were significantly higher in the patients that occured peptic ulcer than that retained gastritis(P0.005). The positive rate of serum Anti-Hp CagA-IgG were significantly higher in the patients that occured erosion of gastric mucosa and intestinal metaplasia than that did not occured erosion of gastric mucosa and intestinal metaplasia (P0.005). But There was not correlation between anti-Hp CagA-IgG and the aggravation of inflammation of gastric mucosa.After H. pylori persistent infection for 10 years, The positive rate of serum anti-Hp IgE were significantly higher in the patients that occured erosion of gastric mucosa and whose inflammation of gastric mucosa aggravated than that did not occured erosion of gastric mucosa and whose H inflammation of gastric mucosa did not aggravated(P0.005).But There was not correlation between anti-Hp IgE and generation of intestinal metaplasia. Conclusions The H. pylori persistent infection can increase the incidence of peptic ulcer, aggravate inflammation of gastric mucosa, and accelerate the generation and progress of intestinal metaplasia. Eradication of H. pylori not only can reduce inflammation of gastric mucosa, but also prevent the generation and progress of intestinal metaplasia. CagA + strain and anti-Hp IgE positive person have more severity outcome of long-term H. pylori infection than CagA - strain and anti-Hp IgE negative person.