2007•Zhongguo bingli shengli zazhiRequires access

Effects of Shengmai San on oxidative damage in mentally stressed mice

Tetsuya Konishi

Abstract

AIM: To investigate the preventive effects of Shengmai San (SMS) on oxidative damage in mentally stressed mice.METHODS: An oxidative stress mouse model was established by moustache-removed. Protein carbonyl and thiobarbituric acid reactive substance (TBARS) formation were determined as the oxidative stress markers.RESULTS: (1)Moustache-cut was founded to significantly enhance the behavioral movements of mice, especially large movements (movement 2 and rearing). SMS pre-administration inhibited the accelerated movements. (2) Protein carbonyl was increased in brain, heart, liver and kidney. TBARS in liver and heart increased in the moustache-cut mice, but SMS pretreatment inhibited the increased protein carbonyl and TBARS.CONCLUSION: SMS has the preventive effects on oxidative damage induced by emotional stress.

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Key concepts: TBARS, Oxidative stress, Thiobarbituric acid, Oxidative damage, Oxidative phosphorylation, Chemistry, Endocrinology, Pharmacology