Comparative study of sufentanil and fentanyl on patients undergoing neurosurgical surgery

Objective:To compare the effects of sufentanil and fentanyl on hemody namics reaction in patients undergoing neurosurgical surgery. Methods:A total o f fifty-six ASA physical status I or II patients scheduled for intracranial tum orresection were randomized to S(sufentanil)or F(fentanyl)group(28 for each).In duction of anesthesia was begun with propofo 2.0 mg/kg,succinylcholine 1.5 mg /kg, group S sufentanil 0.4 μg/kg,group F fentanyl 3 μg/kg.Mechanical ventilatio n w as performed after tracheal intubation,followed by continuous intravenous pumpin g of propofol(4-12 mg/(kg·h)) and sufentanil(0.2 μg/(kg·h))(group S) or fe ntanyl (2 μg/kg)(group F1.Vecuronium 2 mg was injected at intervals of 45-60 min.The pa t ient's blood pressure,heart rate were continuously monitored and recorded. Results:In group F,the Heart Rates(HR)during l min after endotracheal intubation,dural incision and closure,spontaneous breath recovery and after tracheal ext ubation were higher than baseline value(P0.05),while they were higher th an bas eline value during dural incision,spontaneous breath recovery and after trachea l extubation in groupS (P0.05).Group F on MAP at skin incision and after trache al extubation were higher than baseline value(P0.05),but group S was not differ ent from baseline value(P0.05). Conclusion:Sufentanil combining with pr opofol and sevoflurane is more stable applying in the anesthesia induction and mainten ance and sup erior to fentanyl in general anesthesia in intracranial surgery.