Effects of inter-arterial thrombolysis for acute ischemic stroke by different ways of recombinant tissue plasminogen activator after revascularization

Objective To investigate the effects of intra-arterial thrombolysis for acute ischemic stroke by different treatment after revascularization.Methods 93 cases of ultra-acute ischemic stroke patients without visible angiograph ic occlusion on digital subtraction angiogram during intra-arterial thrombolysis of Beijing Shijitan Hospital from Jan uary 2007 to June 2012 were randomized into two group.The control group(44 cases) end recombinant tissue plas minogen activator(r-tPA) intra-arterial thrombolysis and the treatment group(49 cases) continues to r-tPA intra-arte rial thrombolysis until highest approved dose(22 mg).90 d after thrombolysis,National Institutes of Health Stroke Scale scores and modified Rankin Scores(mRS) for prognosis were evaluated for the patients.The situation of neuro logic impairment between groups was judged by NIHSS.The prognosis of neurologic function was evaluated by mRS.Results 24 h after thrombolysis,the treatment group showed a statistically significant decrease in NIHSS score [(3.72 ± 4.80) scores vs(6.24±4.80) scores,P=0.041] and had significant higher rates of the favorable outcome indicated by the mRS(87.7% vs 72.7%,P=0.022) at 90 days than the control group.Conclusion The effects of continuation intraarterial thrombolysis by r-tPA for acute Ischemic Stroke after revascularization is significant and safe.