2006Guangzhou Chemical IndustryRequires access

Microwave Synthesis,Characteristics and Antibacterial Activities of Benzimidazole Derivatives

Liu Jian-hong

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Abstract

1-(p-Methoxybenzyl)-2-(p-thoxyphenyl)-benzimidazole and 1-(p-hydroxybenzyl)-2-(p-hydroxyphenyl)-benzimidazole were snythesized by the condensation of o-phenylenediamine with p-methoxybenzaldehyde and p-hydroxyheozaldehyde under microwave irradiation,and characterized by melting point determination,elements analysis,IR and 1HNMR spectra.Antibacterial activities of the two benzimidazole derivatives were studied.

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1-(p-Methoxybenzyl)-2-(p-thoxyphenyl)-benzimidazole and 1-(p-hydroxybenzyl)-2-(p-hydroxyphenyl)-benzimidazole were snythesized by the condensation of o-phenylenediamine with p-methoxybenzaldehyde and p-hydroxyheozaldehyde under microwave irradiation,and characterized by melting point determination,elements analysis,IR and 1HNMR spectra.Antibacterial activities of the two benzimidazole derivatives were studied.

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Available abstract

1-(p-Methoxybenzyl)-2-(p-thoxyphenyl)-benzimidazole and 1-(p-hydroxybenzyl)-2-(p-hydroxyphenyl)-benzimidazole were snythesized by the condensation of o-phenylenediamine with p-methoxybenzaldehyde and p-hydroxyheozaldehyde under microwave irradiation,and characterized by melting point determination,elements analysis,IR and 1HNMR spectra.Antibacterial activities of the two benzimidazole derivatives were studied.

Key concepts: Benzimidazole, Microwave irradiation, Melting point, Antibacterial activity, Chemistry, Microwave, Condensation, Combinatorial chemistry

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