2006•Zhonghua xingwei yixue yu naokexue zazhiRequires access
Effects of tianeptine on changes of plasticity induced by chronic stress in the rat hippocampal CA3 pyramidal neuronal apical dendrites
Yang Qua
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Abstract
ObjectiveTo explore the effects of tianeptine on changes of plasticity induced by chronic stress (forced-swimming) in the rat hippocampal CA3 pyramidal neuronal apical dendrites. MethodsForty-five male Sprague-Dawley rats were divided randomly into three groups: control group, stress group and stress-medicine groups, 15 rats in each group. The diameter and number of branch of apical dendrites of the hippocampal CA3 pyramidal neurons were measured by using Golgi staining and the cytoskeleton of dendrites were observed by using an electron-microscope. ResultsThe diameter of dendritic shaft of the hippocampal CA3 pyramidal neurons was significantly thicker in the stress group than that in the control group [(5.74±0.87)μm vs (6.41±0.94)μm,P0.05].the number of branch was less than that in the control group (P0.05).The cytoskeleton of them were destructed. ConclusionThe results suggested that tianeptine should inhibit the retraction and cytoskeletonal change of apical dendrites induced by chronic stress in rat hippocampal CA3 pyramidal neurons.