Preemptive Analgesic Effects of Lornoxicam on Patient-Controlled Epidural Analgesia with Morphine in Gynaecological Patients

Objective To determine the preemptive analgesic effects of lornoxicam on patient-controlled epidural analgesia(PCEA) with morphine in patients received gynaecological surgery. Method 52 patients of ASA physical statusⅠ～Ⅱ undergoing abdominal hysterectomy were randomly divided into two groups:Study group (n=26) and control group(n=26). Patients in study group received intravenous lornoxicam 8 mg before incision and suture. Patients in both groups were given patient-controlled epidural analgesia with 0.01% morphine and 0.125% bupivacaine in normal saline. PCEA recipe: loading dose 5ml, continuous infusion 1.5 ml/h,PCA bolus 3 ml, lockout time 20 min. Visual analogue scale(VAS) of 1, 2, 4, 8, 12,24,36,and 48 h were recorded. Pressing times (PCAc) were also recorded for 48 hours and complications such as sedation, dizziness, nausea and vomiting were observed. Result VAS after 12 h were lower in study group than that in control group(P﹤0.05).The differences of VAS after 24,36,48 h between the two groups were not significant(P 0.05). PCAc of the first day in study group was much lower than that in the control group. The rates of nausea and vomiting were 15.3% in study group and 38.4% in control group. Conclusion Preemptive lornoxicam can obviously improve the analgesic effects of PCEA with morphine in patients received gynaecological surgery. The consumption of morphine and the incidence of nausea and vomiting can be decreased.