Endothelium-independent vasorelaxant effect of sodium ferulate on rat thoracic aorta

Objective To investigate the effects of sodium ferulate(SF) on rat isolated thoracic aortas.Methods Isometric tension was recorded the reaction that rat aorta and endothelium-denuded aorta response to phenylephrine and high potassium,and the effect of sodium ferulate on rat aorta and de-endothelialized rat aortic diastolic function.Results SF(0.1-30 mmol/L) relaxed the isolated aortic rings precontracted with phenylephrine(PE) and high-K+ in a concentration-dependent manner with respective pD2 of 2.73±0.02 and 2.57±0.06(P 0.05).Mechanical removal of endotheliumdid not significantly modify the SF-induced relaxation.Conclusion These results indicate that SF acts directly as a non-selective relaxant to vascular smoothmuscle.