Prognostic analysis of patients with colorectal cancer with synchronous liver metastasis after operation

Objective To analyze the prognostic factors of patients with colorectal cancer( CRC) with synchronous liver metastasis after operation.Methods CRC resection and simultaneous resection of liver metastases were performed in 76 cases of CRC with synchronous liver metastasis.The survival was analyzed.The suspected prognostic factors were analyzed by log-rank method and Cox model.Results The median survival was 38 months after operation( 8 to 109 months),with three year survival of 56.58% and five year survival of 35.53%.Log-rank test indicated that significant prognostic factors were primary tumor T staging,N staging,histologic differentiated grade,preoperative CEA level,and the size and the number of liver metastases.Furthermore,multivariate analysis showed that preoperative CEA level,and the size and number of liver metastasis were the most important prognostic factors.Conclusion Simultaneous resection of CRC and liver metastasis is necessary for patients with CRC with synchronous liver metastasis.The size and the number of liver metastases,and the preoperative CEA level are closely related with the prognosis.