The effect of cholic acid on liver function in cirrhotic rats with sabtotal hepatectomy

Objective To evaluate the effect of cholic acid on liver function in cirrhotic rats with partial hepatectomy.Methods Twenty four cirrhotic rats with sabtotal hepatectomy were randomly divided into cholic acid group(n=12) and control group(n=12).Control group was fed with normal diet for one week,cholic acid group was fed with 0.2% cholic acid diet for one week.One week later,the rate of bile secretion,the total bile acids(TBA) content of bile,mitotic index(MI) of liver cell and proliferating cell nuclear antigen(PCNA) labeling index of hepatocyte and contents of DNA in cell nuclear were determined.Results Compared with the control group,the rate of bile secretion,the TBA content of bile,serum ALB,MI,PCNA labeling index and contents of DNA in cell nuclear were significantly increased(P0.01),serum AST and ALT were significantly decreased(P0.01) in cholic acid group.Conclusion Cholic acid can enhance the rate of bile secretion and the TBA content of bile,promote recovery of liver function and liver regeneration after subtotal hepatectomy in cirrbotic rats.