EFFECTS OF CYCLOSPORIN A ON PULMONARY FIBROSIS IN RATS

Objective:To study the effects of cyclosporin A on pulmonary fibrosis induced by bleomycin in rats.Methods:Forty five wistar rats were divided into three groups in random:Saline,untreated model and cyclosporin A treated group.Bronchoalveolar lavage were performed in these rats for the enumeration of cells.Lung tissues of tested animals were pathologically observed and immunohistochemically stained.Results:Seven days later after using bleomycin instillation,Serious alveolitis presented,and the serious pulmonary fibrosis formed at 28th day.In contrast to the bleomycin group,in the early course of the cyclosporin A treated group,there was mild inflammatory changes observed under microscope.The expressions of FN and PDGF decreased more in the cyclosporin A treated group compared with those of the same stage in the bleomycin group,There was almost disappearance of pulmonary fibrosis in the cyclosporin A treated group at 28th day.Conclusion:Cyclosporin A may have an inhibitory effect on the process of the pulmonary fibrosis.