THE EFFECTS OF SEVOFLURANE AND PROPOFOL ON HEMODYNAMICS DURING TRACHEAL ANESTHESIA

Objective To investigate the effects of propofol and sevoflurane on hemodynamics during tracheal anesthesia.Methods Sixty ASA Ⅰ orⅡ patients undergoing elective upper abdominal surgery under general anesthesia were randomly allocated to one of three groups with 20 patients in each group:group Ⅰ anesthesia induced with sevoflurane,and maintained with sevoflurane inhalation;group Ⅱ,anesthesia induced with propofol,and maintained with propofol injection;group Ⅲ,anesthesia induced with sevoflurane+ TCI propofol(1 μg·mL-1),and maintained with sevoflurane+ TCI propofol(1 μg·mL-1).BIS was maintained at 45-55 after tracheal intubation during maintenance of anesthesia.SBP,DBP,MAP and HR were continuously monitored during anesthesia.Results Immediately after tracheal intubation,HR of group Ⅰand Ⅱ was significantly increased than before(F=18.84-23.17,q=7.93-7.98,P0.05),but no significant changes was found among the three groups after tracheal intubation(P0.05).Before tracheal intubation,SBP,DBP and MAP of the three groups reached the lowest level(F=9.76-18.47,q=8.07-13.21,P0.01),which became higher after tracheal intubation,reached a maximum at 1-2 min after tracheal intubation(q=4.36-6.75,P0.05),dropped to the pre-tracheal intubation level at 7 min after tracheal intubation(P0.05).In the inter-group comparison,SBP,DBP,and MAP of group Ⅰand group Ⅲ were significantly different from group Ⅱ(F=7.86-21.30,q=5.41-8.57,P0.01),but no significant difference existed between the group Ⅰand group Ⅲ(P0.05).Conclusion Inhalation of sevoflurane can leads to less variation in hemodynamics during tracheal intubation than propofol injection.It is a better option for anesthesia induction.