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2008•Journal of Shantou University Medical CollegeRequires access

Influence of Tashinone II A-sulfoacid-natrum on the Electrophysiology of Rabbit's Left Ventricle in vivo and the Experimental Arrhythmia

Qiu Han-yin

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Abstract

Objective: To study the influence of tashinoneⅡa-sulfoacid-natrum(TSN)on the electrophysiology of rabbit's left ventricle in vivo and the experimental arrhythmia.Methods: The electrode was inserted into rabbit's ventricular wall to observe different doses(0.5,1,2,4 mg/kg)of the TSN on the influence of the rabbit's ventricle electrophysiology.The arrhythmic model induced by BaCl2 and chloroform-adnephrin was used to study the influence of experimental arrhythmia.Results: Low-dose TSN had no obviously influence on the electrophysiology of rabbit's ventricle.Large-dose TSN could prolong rabbit's ventricular relative refractory period、ventricular effective refractory period、ventricular fibrillation threshold,and reduced the occurrence of arrhythmia induced by BaCl2 and chloroform-adnephrin.Conclusion: TSN may have the efficacy to increase electrical stability of the cardiac muscle and reduce the occurrence of arrhythmia.

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What this paper is about

Objective: To study the influence of tashinoneⅡa-sulfoacid-natrum(TSN)on the electrophysiology of rabbit's left ventricle in vivo and the experimental arrhythmia.Methods: The electrode was inserted into rabbit's ventricular wall to observe different doses(0.5,1,2,4 mg/kg)of the TSN on the influence of the rabbit's ventricle electrophysiology.The arrhythmic model induced by BaCl2 and chloroform-adnephrin was used to study the influence of experimental arrhythmia.Results: Low-dose TSN had no obviously influence on the electrophysiology of rabbit's ventricle.Large-dose TSN could prolong rabbit's ventricular relative refractory period、ventricular effective refractory period、ventricular fibrillation threshold,and reduced the occurrence of arrhythmia induced by BaCl2 and chloroform-adnephrin.Conclusion: TSN may have the efficacy to increase electrical stability of the cardiac muscle and reduce the occurrence of arrhythmia.

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Available abstract

Objective: To study the influence of tashinoneⅡa-sulfoacid-natrum(TSN)on the electrophysiology of rabbit's left ventricle in vivo and the experimental arrhythmia.Methods: The electrode was inserted into rabbit's ventricular wall to observe different doses(0.5,1,2,4 mg/kg)of the TSN on the influence of the rabbit's ventricle electrophysiology.The arrhythmic model induced by BaCl2 and chloroform-adnephrin was used to study the influence of experimental arrhythmia.Results: Low-dose TSN had no obviously influence on the electrophysiology of rabbit's ventricle.Large-dose TSN could prolong rabbit's ventricular relative refractory period、ventricular effective refractory period、ventricular fibrillation threshold,and reduced the occurrence of arrhythmia induced by BaCl2 and chloroform-adnephrin.Conclusion: TSN may have the efficacy to increase electrical stability of the cardiac muscle and reduce the occurrence of arrhythmia.

Key concepts: Ventricle, Refractory period, Electrophysiology, Effective refractory period, Ventricular fibrillation, Cardiology, Internal medicine, In vivo

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Influence of Tashinone II A-sulfoacid-natrum on the Electrophysiology of Rabbit's Left Ventricle in vivo and the Experimental Arrhythmia — Research Paper | ScholarLens