The expression of β-catenin in gastric diseases and pathological implications

Objecive To investigate the expression of β-catenin in various diseases and the function of gastric carcinogenesis and differentiation.Methods A total of 300 patients the expression of β-catenin proteins in the gastric mucosa were detected by immunohistochemistry.Results The expression rates of β-catenin in the nucleus were significantly lower in CG and GA than in GC(P0.05).In GC cases,the expression rates of β-catenin were significantly higher in intestinal type than in diffuse type(P0.05).Conclusion The expression of β-catenin is progressively decreased following the process of GC tumorigenesis,with β-catenin expression being translocated from the cytoplasm to the nucleus.the expression of β-catenin in the cytoplasm and nucleus in patients with gastric cancer,especially the intestinal type.