2009•Sichuan Medical JournalRequires access
The expression and significance of RANTES in nasal mucosa and lung in model of allergic rhinitis
Tang Si-quan
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Abstract
Objective To study the expression and distributing of RANTES in nasal mucosa and lung tissue in model of allergic rhinitis.Methods Twenty SD rats were randomly divided into allergic rhinitis(AR)group and normal control group.Ovalbumin(OVA)sensitized and challenged rats were used as the model of allergic rhinitis.The expression of RANTES in nasal mucosa and lung tissue was detected by immunohistochemistry.Results RANTES positive cell and the expression in nasal mucosa and lung of AR group were significantly higher than that of normal control group(P0.01).The number of RANTES positives cells in nasal mucosa was significantly positively correlated with the number of RANTES positives cells in lung tissue of ARgroup(r=0.94,P0.01).Conclusion High expression of RANTES in nasal mucosa and lung tissue of AR of rats,revealed there was distinct consistency and correlation in respect of inflammatory reaction of the upper and lower respiratory tracts.