A study of duloxetine in the trentment of tumor patients with depression disorders

Objective To explore the clinical efficacy and safety of duloxetine in treatment of tumor patients with depression disorders. Methods 60 patients were randomly divided into groups of 30 ones each to one group was plused duloxetine for 8 weeks. Depressive emotions were assessed with the Hamilton Depression Rating Scale( HAMD) and adverse reactions with Treatment Emergent Symptom Scale( TESS) before treatment and at the the2nd,4thand 8thweek. Results Improvement rates of depression emotion were respectively 76. 7% in the research and 26. 7% in the no duloxetire group at the end of 8thweek,the former were significantly higher than the latter( P 0. 01),scores of both the HAMD lowered more sighiticantly in the research than in the no duloxetine group( P 0. 05). Adverse reactions of the two groups were not different. Conclusion Duloxetine has a notable effect and high safety in the treatment of patients with depression disorders,can improves patients' quality of life significantly.