Comparison of the Effects of Postoperative Patients Controlled Analgesia of Morphine with Tramadol in Elder

Objective To compare the effects and safety of postoperative patient controlled intravenous analgesia(PCIA) of morphine with tramadol in elderly patients undergoing upper abdominal surgery.Methods Forty ASA Ⅰ～Ⅲ postoperative patients aged 70～83 years undergoing selective abdominal operation were randomly allocated into two groups(n=20):M group and T group.All patients initially received 0.5mg/kg bolus dosage of tramadol before administrating analgesia.Then 25mg of morphine diluted with 100ml of 0.9% NaCl was infused with PCA infuser(lockout=15min,PCA=0.5ml) by patients accompanied by continuous background infusion with a rate of 2ml in M group for 24 hours after operation,while 400mg of tramadol was done in T group.quality of postoperative analgesia was assessed by visual analogue scale(VAS) on postoperative four time-points(4h,8h,12h,24h).Side effects such as severe sedation,respiratory depression,vomiting and hypotension were observed for 24 hours after operation.Results The quality of postoperative analgesia was similar in both groups.However,a significant decreasing of respiratory depression in T group.Conclusions Tramadol PCIA is a safe and effective postoperative analgesia method for elder patients.