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THE CHANGES OF NaN/SNS2 Na~+ CHANNEL EXPRESSION IN DORSAL ROOT GANGLION NEURONS IN RATS WITH CHRONIC CONSTRICTION INJURY OF SCIATIC NERVE

Wei Wei

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Abstract

The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery. The transcript of NaN, a sensory neuron specific TTX R sodium channel, was significantly down regulated as well as the TTX R sodium current. The TTX R current density was significantly decreased in CCI group. At the same time, the properties of the TTX R currents revealed in the activation curve and steady state inactivation curve were unchanged. These results may provide at least a partial basis for the hyperexcitability of DRG neurons that contributes to hyperalgesia in this model.

About this research paper

What this paper is about

The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery. The transcript of NaN, a sensory neuron specific TTX R sodium channel, was significantly down regulated as well as the TTX R sodium current. The TTX R current density was significantly decreased in CCI group. At the same time, the properties of the TTX R currents revealed in the activation curve and steady state inactivation curve were unchanged. These results may provide at least a partial basis for the hyperexcitability of DRG neurons that contributes to hyperalgesia in this model.

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Available abstract

The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery. The transcript of NaN, a sensory neuron specific TTX R sodium channel, was significantly down regulated as well as the TTX R sodium current. The TTX R current density was significantly decreased in CCI group. At the same time, the properties of the TTX R currents revealed in the activation curve and steady state inactivation curve were unchanged. These results may provide at least a partial basis for the hyperexcitability of DRG neurons that contributes to hyperalgesia in this model.

Key concepts: Dorsal root ganglion, Sodium channel, Sciatic nerve, Medicine, Constriction, Sciatic nerve injury, Nerve injury, Hyperalgesia

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THE CHANGES OF NaN/SNS2 Na~+ CHANNEL EXPRESSION IN DORSAL ROOT GANGLION NEURONS IN RATS WITH CHRONIC CONSTRICTION INJURY OF SCIATIC NERVE — Research Paper | ScholarLens