Changes of serum levels of VEGF and endostatin in lung cancer patients and their significance

Objective To evaluate the change of serum VEGF and endostatin(ES) levels in lung cancer patients before and after operation,chemotherapy alone or with and their clinical significance.Methods Serum VEGF and ES levels were detected and compared in 20 normal control persons and 80 patients with lung cancer by enzyme linked immunosorbant assay(ELISA).Results Serum VEGF and ES levels in lung cancer group were significantly higher than those in control groups(P0.01).Serum VEGF and ES levels were closely related to tumor size and clinical stage of tumors,but not related to the histological classification(P0.05).Serum VEGF levels in lung cancer patients on Day 1 post-operation were significantly higher than these before operation(P0.01),and the VEGF levels on day 7 post-operation were significantly higher than those before operation and on day 1 post-operation(P0.01).Serum ES levels in patients who had effective response to chemotherapy alone on the Day 1 post-chemotherapy were significantly higher than those before chemotherapy and on Day 14 post-chemotherapy(P0.05).Serum VEGF levels in patients who had ineffective response to chemotherapy alone on Day 14 were significantly higher than those before chemotherapy and on Day 1 post-chemotherapy(P0.05).Serum VEGF levels in patients who had effective response to chemotherapy alone or with on Day 1 post-chemotherapy were significantly lower than those before Chemotherapy(P0.05),and the VEGF levels on Day 14 post-treatment were significantly lower than those before treatment and on Day 1 post-treatment(P0.05).The effective rate was 56.67% in the treatment group,and 26.67% in the control group,The VEGF levels in CR and PR patients of the treatment group were significantly lower than those in the control group after treatment(P0.05).Conclusion The increased serum levels of VEGF and ES were associated with tumor size,clinical stage of tumors,operation and chemotherapy in lung cancer patients.This is useful for treatment and prognostic judgement of lung cancer patients.Serum VEGF and ES levels were not related to the histological classification.Chemotherapy combined Endostar is superior to chemotherapy alone in the treatment of Lung neoplasms.VEGF,as a biomarker,may be useful in predicting the efficacy of the combined treatment.