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Study of the effect of BMP on the biological activity of osteoblast in healthy people in vitro

Shi Shushan

Abstract

Objective To investigate the effect of bone morphogenetic protein(BMP)on the biological activity of osteoblast of healthy people in vitro.Methods The osteoblast was stimulated with BMP at the concentrations of 0.02,0.1,1μg/ml respectively,and the effects of BMP at different concentrations were detected by MTT.The osteoblast was stimulated with BMP at the concentration of 0.1 μg/ml,and the levels of alkaline phosphatase(ALP)and bone gla protein(BGP)of osteoblast were measured.Results BMP could promote osteoblast to synthesize more ALP and BGP.Conclusion BMP can increase the activity of osteoblast,which is concentration-dependent.

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Key concepts: Osteoblast, Alkaline phosphatase, Bone morphogenetic protein 2, In vitro, Bone morphogenetic protein, Medicine, Bone morphogenetic protein 7, Bone formation