Diagnosis of focal hepatic lesions with contrast-enhanced gray-scale ultrasonography with technique CPS and CCI

Objective To study the value of contrast enhanced harmonic gray-scale ultrasonography (CE-GUS) in the differentiation of focal hepatic lesions. Methods Thirty-nine solid focal lesions were examined by using contrast pulse sequencing (CPS) and coherent contrast imaging (CCI) imaging technique with SonoVue enhanced ultrasonography. Thirty-two lesions were also examined with contrast enhanced fundamental color Doppler imaging (CE-CDFI). Results The blood flow signal within lesions visualized by grey-scale contrast enhanced ultrasonography (CE-GUS, 97.44%) was significantly higher than that of result with CE-CDFI ( P 0.05). The positive diagnoses with CE-GUS according to the characteristic and dynamic enhancement (92.3%, 36/39) was significantly higher than that of conventional ultrasound (23.1%) as well as CE-CDFI (50%), P 0.05. Conclusion CPS and CCI, the contrast enhanced grey-scale ultrasonography technique, were useful for visualization of tissue perfusion and differentiation diagnosis for hepatic focal lesions.