Contraction effects of angiotensin II on anoxia and non-anoxia SHR aorta and guinea pig aorta

This study was designed to investigate the effects of angiotensinⅡ on non-anoxia and anoxia SHR aorta and guinea pig aorta. We found that AngⅡ3￣300 nmol·L-1 significantly increased the contraction of guinea pig aorta in dose-dependent manner. Aorta contraction in guinea pig was more sensitive to AngⅡthan in non-anoxia SHR. After anoxia, the aorta contraction induced by AngⅡ was markedly increased in guinea pig but not in aorta of SHR. In addition, anoxia significant dicreased the content of AngⅡ of SHR aorta. However, there was no difference between non-anoxia and anoxia aorta of guinea pig in the concentration of AngⅡ.The results suggested that contraction responses of aorta to AngⅡ may be different between SHR and the guinea pig.