Clinical Significance of Serum Levels of Soluble Intercellular Adhesion Molecule-1 in Children with Mycoplasma Pneumonia

Objective To investigate the levels of serum soluble intercellular adhesion molecule-1(sICAM-1) in children with mycoplasma pneumonia(MPP) in different clinical periods and to evaluate the role of sICAM-1 in pathogenesis of MP-induced asthma.Methods The levels of serum sICAM-1 were detected via enzyme linked immunosorbent assay(ELISA) and eosinophilic granulocyte counts(EOC) in induced sputum were measured in 46 children with MP-induced asthmatic acute attack(groupⅠ),38 children with simple MPP(non-asthma)(group Ⅱ) and 40 healthy controls(group Ⅲ) in acute and remission periods,respectively.The children in groupⅠandⅡwere followed up for 6 months and observed the incidence of asthmatic attacks.Results The levels of serum sICAM-1 and EOC in induced sputum in three groups were(558.6±66.42)mg/L,(425.64±68.56)mg/L,(206.26±56.24)mg/L,(8.4±1.8)/100,(5.0±1.4)/100 cells in acute period,there were significant differences between groupⅠand groupⅡand groupⅢ(P0.01);in remission period,the levels of serum sICAM-1 and EOC in induced sputum in two MPP groups were(338.51±60.38)mg/L,(325.64±68.56)mg/L,(5.2±2.8),(4.8±2.6)/100 cells,there were not differences between groupⅠand groupⅡ(P0.05).Both levels of serum sICAM-1 and EOC in induced sputum in groupⅠand groupⅡ were significantly higher than that in group Ⅲ(P0.01).After 6 months,28 cases were diagnosed as asthma(60.9%) in groupⅠand 22 cases(57.9%) in groupⅡ,no difference was found statistically(P0.05).Conclusion Our observations demonstrate that the levels of serum sICAM-1 in children with MPP especial induced asthmatic attack are increased significantly and sICAM-1 plays a important role in pathogenesis of MP-induced asthma.