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2012•Zhongguo fuyou baojianRequires access

Detection of methylation of FHIT gene promoter among Uigur women with cervical squamous cell carcinoma

Wei Zheng

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Abstract

Objective:To analyze the correlation between methylation of fragile histidine triad(FHIT) gene promoter and the occurrence of cervical squamous cell carcinoma among Uigur women.Methods:Methylation specific PCR(MSP) was used for methylation detection of cervical squamous cell carcinoma tissue of 45 Uigur women and cervical tissue of 34 normal Uigur women.Results:Among 34 Uigur women with normal cervical tissue,two women with methylation of FHIT gene promoter were found,the rate of methylation was 5.88%;among 45 Uigur women with cervical squamous cell carcinoma,15 Uigur women with methylation of FHIT gene promoter were found,the rate of methylation was 33.33%.Conclusion:There is correlation between methylation of FHIT gene promoter and the occurrence of cervical caner among Uigur women.

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What this paper is about

Objective:To analyze the correlation between methylation of fragile histidine triad(FHIT) gene promoter and the occurrence of cervical squamous cell carcinoma among Uigur women.Methods:Methylation specific PCR(MSP) was used for methylation detection of cervical squamous cell carcinoma tissue of 45 Uigur women and cervical tissue of 34 normal Uigur women.Results:Among 34 Uigur women with normal cervical tissue,two women with methylation of FHIT gene promoter were found,the rate of methylation was 5.88%;among 45 Uigur women with cervical squamous cell carcinoma,15 Uigur women with methylation of FHIT gene promoter were found,the rate of methylation was 33.33%.Conclusion:There is correlation between methylation of FHIT gene promoter and the occurrence of cervical caner among Uigur women.

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Available abstract

Objective:To analyze the correlation between methylation of fragile histidine triad(FHIT) gene promoter and the occurrence of cervical squamous cell carcinoma among Uigur women.Methods:Methylation specific PCR(MSP) was used for methylation detection of cervical squamous cell carcinoma tissue of 45 Uigur women and cervical tissue of 34 normal Uigur women.Results:Among 34 Uigur women with normal cervical tissue,two women with methylation of FHIT gene promoter were found,the rate of methylation was 5.88%;among 45 Uigur women with cervical squamous cell carcinoma,15 Uigur women with methylation of FHIT gene promoter were found,the rate of methylation was 33.33%.Conclusion:There is correlation between methylation of FHIT gene promoter and the occurrence of cervical caner among Uigur women.

Key concepts: FHIT, Methylation, Gene, DNA methylation, Promoter, Basal cell, Medicine, Cervical carcinoma

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Detection of methylation of FHIT gene promoter among Uigur women with cervical squamous cell carcinoma — Research Paper | ScholarLens