2010•Proceeding of Clinical MedicineRequires access
Effect of edaravone on the expression of p-Bad in the rat model of focal cerebral ischemia-reperfusion
Baoming Xie
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Abstract
Objective:To explore the expresion of p-Bad in the model of focial cerebeal ischemia-reperfusion and the effect of edaravone.Methods:The model of focial cerebral ischemia-reperfusion injury was made.The pathological changes was observed by HE staining method.The average OD of the phosphorylation Bad was detected by immunohistochemisery at different time after ischemia.Results:Expression of p-Bad in model group was elevatory at 2 h after ischemia compared with the cham operation,it reached a peak level at 4 h after ischemia,then declined.Expression of p-Bad in edaravone treated group at all time points were significant increased.Conclusion:The protein expression of p-Bad may participated in the occueance of ischemia cellular injury,edaravone obviously inhibited transient focal cerebral ischemia injury through up-regulate the expression of p-Bad and show a neuroprotective effect.