The clinical analysis on 83 cases of primary biliary cirrhosis

Objective To explore the clinical and pathological features of primary biliary cirrhosis (PBC). Methods Clinical data of 83 patients with PBC has been analyzed retrospectively. Results All 83 patients, the male to female ratio was 7︰76. The manifestation were fatigue, anorexia, jaundice, splenomegaly, ascites, pruritus, Sj?gren's syndrome and hepatomegalia in order. The levels of serum alkaline phosphatase (ALP) and serum γ glutamyl transpeptidase (GGT) were significanly elevated at level of (330.58 ± 255.03) U/L and (255.58 ± 234.65) U/L respectively. The positive rate of anti-mitochondrial antibody (AMA) and anti-mitochondrial antibody M2 subtype (AMA-M2) were 88% and 71.1%, respectively. The results of 21 cases with liver histopathological examination indicated that the main changes focus on small bile duct. There were significant difference in course of disease and total bilirubin between Ⅰ, Ⅱstage and Ⅲ, Ⅳ stage (P 0.05). Conclusions PBC most often occur in women. Clinical manifestations lack of specificity. The levels of serum ALT and GGT were increased significantly, and the positive AMA/AMA-M2 are key feature. The course of disease and the total bilirubin are relate to histopathological progression.