A comparison of three controlled ovarian stimulation protocols in decreased ovarian reserve patients

Objective: To compare the stimulation effects and the clinical outcomes of GnRH agonist long protocol,GnRH agonist short protocol and GnRH antagonist protocol regimens in decreased ovarian reserve patients in IVF / ICSI cycles.Method: Women for in vitro fertilization(IVF) or intracytoplasmic sperm injection(ICSI)-embryo transfer(ET) therapy due to the tubal and / or male factors were included in this study.169 controlled ovarian stimulation cycles were analyzed.Women general characteristics,basal and hCG day hormones,oocytes retrieved,fertilization,transfer embryos,duration of COS,dosage of ganadotropins and pregnant outcomes were evaluated.Results: There was no significant difference on the general characteristics,hormone levels,retrieved oocytes and fertilization gametes in three protocols(P 0.05).The usage of gonadotropins and duration of COS in GnRH agonist short protocol and GnRH antagonist protocol groups were significantly less than GnRH agonist long protocol group.The clinical pregnancy rates were 29.57%,23.45%,33.69% respectively in GnRH agonist long,short and antagonist group,there was no significant difference among them(P 0.05).Conclusion: GnRH antagonist protocol is likely to be an alternative method for COH in decreased ovarian reserve patients.