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Research of mechanism that inhibitor of Bcl-2 S1 induce SKOV3 cell apoptosis

Jing Zhang

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Abstract

Objective To investigate the apoptosis mechanism induced by micromolecule compound S1 in human ovarian cancer cells SKOV3.MethodCell viability was detected by MTT to S1 in ovarian cancer cells SKOV3;The apoptosis rate of SKOV3 cells was determined by Flow Cytometry analysis;Western blotting was used to analyze the expression of the protein of Mcl-1.ResultsMTT assay indicated that compared with control group,S1 can decrease the cell viability of SKOV3 cells.It significantly activated the apoptosis in SKOV3 cells measured by Flow Cytometry analysis treated with S1.Western blotting showed the result that apoptosis-relative protein Mcl-1 was inhibited by S1 in human Ovarian cancer cells.ConclusionThe main mechanisms that S1 induce SKOV3 cell apoptosis through the way that inhibit Mcl-1 protein.

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What this paper is about

Objective To investigate the apoptosis mechanism induced by micromolecule compound S1 in human ovarian cancer cells SKOV3.MethodCell viability was detected by MTT to S1 in ovarian cancer cells SKOV3;The apoptosis rate of SKOV3 cells was determined by Flow Cytometry analysis;Western blotting was used to analyze the expression of the protein of Mcl-1.ResultsMTT assay indicated that compared with control group,S1 can decrease the cell viability of SKOV3 cells.It significantly activated the apoptosis in SKOV3 cells measured by Flow Cytometry analysis treated with S1.Western blotting showed the result that apoptosis-relative protein Mcl-1 was inhibited by S1 in human Ovarian cancer cells.ConclusionThe main mechanisms that S1 induce SKOV3 cell apoptosis through the way that inhibit Mcl-1 protein.

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Available abstract

Objective To investigate the apoptosis mechanism induced by micromolecule compound S1 in human ovarian cancer cells SKOV3.MethodCell viability was detected by MTT to S1 in ovarian cancer cells SKOV3;The apoptosis rate of SKOV3 cells was determined by Flow Cytometry analysis;Western blotting was used to analyze the expression of the protein of Mcl-1.ResultsMTT assay indicated that compared with control group,S1 can decrease the cell viability of SKOV3 cells.It significantly activated the apoptosis in SKOV3 cells measured by Flow Cytometry analysis treated with S1.Western blotting showed the result that apoptosis-relative protein Mcl-1 was inhibited by S1 in human Ovarian cancer cells.ConclusionThe main mechanisms that S1 induce SKOV3 cell apoptosis through the way that inhibit Mcl-1 protein.

Key concepts: Apoptosis, Flow cytometry, Blot, Viability assay, Medicine, MTT assay, Cancer research, Cell

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