Study on Correlation between Sex Hormones and Female Climacteric Hypertension

Objective: To detect the sex hormone levels in menopausal women with hypertension in different syndromes,and provide the objective basis for hypertension in female climacteric syndrome type.Methods: This study collected 210 cases of hypertension in menopausal hypertensive patients.30 cases of selected menopausal women with normal blood pressure were as controls.The menopausal syndrome patients with essential hypertension were divided into both deficiency of heart and spleen group(40 cases),liver depression and phlegm accumulation group(36 cases),Yin deficiency and internal dryness group(98 cases),both deficiency of Yin and Yang group(36 cases).The serum sex hormone levels of different syndromes and control groups were detected to do the statistical analysis and comparison.Results: E 2 levels in four TCM syndrome types groups were lower than those in the control group.The progesterone(P) and follicle-stimulating hormone(FSH) levels were higher than those in the control group.E 2,E 2 / T level of Yin deficiency and internal dryness group was lower than the rest syndrome groups and control group.E 2 / P levels were lower than both deficiency of heart and spleen group.The FSH level in the four syndromes had an order as follows: Yin deficiency and internal dryness liver depression and phlegm accumulation both deficiency of heart and spleen both deficiency of Yin and Yang group.Further subgroup analyses of female climacteric hypertension,the serum levels of estradiol,E 2 / P,E 2 / T levels of hypertension 2 level group were lower than those of the climacteric hypertension 1 level group.The FSH level was higher than that of 1 level group.E 2 and E 2 / T levels in Yin deficiency and internal dryness syndrome group in hypertension 1 level and 2 level were significantly lower than those of other three type groups.Conclusion: The sex hormone disorder has a certain role in female climacteric hypertension.With elevated levels of climacteric hypertension,the sexual hormone disorder condition can be aggravated.Changes of E 2 and E 2 / T levels in female climacteric hypertension are obvious,which can be used as the objective index of Yin deficiency and internal dryness syndrome,and the levels of FSH in four groups of TCM syndromes in different levels can be used as the index characteristic to distinguish four syndrome types.