2002•Chinese journal of integrated traditional and Western medicineRequires access

Study of Qishe Jingkang Pill on Expression of Basic Fibrocyte Growth Factor,Insulin-Like Growth Factor-I mRNA in Degenerated Cervical Intervertebral Disc in Rats

Yu Xu

Abstract

Objective:To study the effects of Qishe Jingkang Pills(QSJKP)on the expression of basic fibrocyte growth factor(bFGF)and insulin-like growth factor-I(IGF-I)mRNA in the degenerated intervertebral disc.Methods:The model of rats degeneration of cervical intervertebral discs caused by imbalance between the dynamic and static force was established.The gene expression of bFGF and IGF-1 mRNA in degeneration cervical intervertebral disc was assayed by reverse transcription polymerase chain reaction(RT-RCR).Results: The expression of bFGF mRNA in the intervertebral disc in model group was markedly higher than that in normal group,and some sig- nificant difference was shown in comparing with QSJKP.The expression of IGF-I mRNA in the intervertebral disc in model group was obviously lower than that in normal group,and significant difference was shown in comparing with QSJKP and model group.Conclu- sion:QSJKP may use to down-regulation gene expressed of bFGF and up-regulation of IGF-I mRNA.

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Key concepts: Basic fibroblast growth factor, Fibrocyte, Intervertebral disc, Growth factor, Messenger RNA, Insulin-like growth factor, Gene expression, Endocrinology