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2011•The Chinese Journal of DermatovenereologyRequires access

Clinical Affcction on some Cytokines in Patients with Condyloma Acuminatum after Treatment with PDT Combine CO_2 Laser

Lihong Mei

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Abstract

Objective To investigate the changes of serum IL-2,IL-6,IL-8,IL-12 and TNF-α levels in patients with condyloma acuminatum(CA) before and after treatment and its role in the immune pathogenesis of CA.Methods Serum IL-2,IL-6,IL-8,IL-12 and TNF-α were detected by ABC-ELISA both before and after treatment with ALA-PDT combined CO2 Laser in 35 patients with condyloma acuminatum and 35 controls.Results The levels of seurm IL-6, IL-12 were singificantly lower in the patients than those in controls, while the serum TNF-α were significantly higher before treatment. After treatment,the levels of all serum cytokines above were changed(all P0.05),and no significant difference with controls(P0.05). Conclusion The levels of serum IL-6,IL-12, TNF-α can be changed significantly by PDT combined CO2 Laser

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What this paper is about

Objective To investigate the changes of serum IL-2,IL-6,IL-8,IL-12 and TNF-α levels in patients with condyloma acuminatum(CA) before and after treatment and its role in the immune pathogenesis of CA.Methods Serum IL-2,IL-6,IL-8,IL-12 and TNF-α were detected by ABC-ELISA both before and after treatment with ALA-PDT combined CO2 Laser in 35 patients with condyloma acuminatum and 35 controls.Results The levels of seurm IL-6, IL-12 were singificantly lower in the patients than those in controls, while the serum TNF-α were significantly higher before treatment. After treatment,the levels of all serum cytokines above were changed(all P0.05),and no significant difference with controls(P0.05). Conclusion The levels of serum IL-6,IL-12, TNF-α can be changed significantly by PDT combined CO2 Laser

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Available abstract

Objective To investigate the changes of serum IL-2,IL-6,IL-8,IL-12 and TNF-α levels in patients with condyloma acuminatum(CA) before and after treatment and its role in the immune pathogenesis of CA.Methods Serum IL-2,IL-6,IL-8,IL-12 and TNF-α were detected by ABC-ELISA both before and after treatment with ALA-PDT combined CO2 Laser in 35 patients with condyloma acuminatum and 35 controls.Results The levels of seurm IL-6, IL-12 were singificantly lower in the patients than those in controls, while the serum TNF-α were significantly higher before treatment. After treatment,the levels of all serum cytokines above were changed(all P0.05),and no significant difference with controls(P0.05). Conclusion The levels of serum IL-6,IL-12, TNF-α can be changed significantly by PDT combined CO2 Laser

Key concepts: Condyloma Acuminatum, Pathogenesis, Medicine, Immune system, Tumor necrosis factor alpha, Significant difference, Immunology, Gastroenterology

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Clinical Affcction on some Cytokines in Patients with Condyloma Acuminatum after Treatment with PDT Combine CO_2 Laser — Research Paper | ScholarLens